Discussion

Hi Nwume, I think that the search in Reaxys that Dr. Ridley describes above is an excellent way to delve into a topic and explore what areas are of most interest to you. He also shows you how to use the filters to narrow down hitsets. If you are specifically interested in Ziprasidone, enter that name into the Quick Search in Reaxys. You will get a Substance Record and over 7000 Document Records. I encourage you to spend some time exploreing the Substance Record to get a feel for the tremendous amount of information it contains. You have identifier information, a link to the Synthesis Planner, and a large body of property information: physical, spectral, bioactivity, uses and more. Each excerpted property entry is connected to the citation of the source document so you can always look at the context in which the data were reported. Also explore the Document Records. They are first organized by Relevance but you can use the filters to, for example, look at only Reviews or other document types. I personally like using the Index Term Filter. It quickly gives me an overview of the topics addressed in the full set of documents to (a) get a feel for what topics are most commonly associated with and addressed regarding Ziprazidone and (b) select the documents that address topics that I find interesting. The Index Terms in each Document Record is also a very interesting way of finding other search terms you may not have thought of and that can help narrow or expand your search. Give it a shot and see what you find. Have fun! Anja

Time zones! (Your first post that I answered was before 6:00 my time.) Actually, Reaxys does have "mechanism" as an index term in Reaction Records, but it is in the Subject Studied Field. Query builder => Search properties: subject => Drag Subject Studied to the working space. To see terms in the field, click Lookup icon at the very right of the field and in this case you see 16 terms, one of which is: mechanism. Check the box next to it, then Transfer. (Lookup is a very handy tool to help select terms in any field in Query builder.) If you now Search (Reactions) you get around 75,000 reactions that have been specifically indexed as mechanism. To narrow these, click back to Query builder, click Structure icon at the top of the screen, and then build the structure of your cyclohexene anhydride adduct. Click the arrow icon (bottom of panel on left), then click to the left of your structure and drag towards the structure. You then have drawn an arrow that indicates to Reaxys you want the structure to be a product in a reaction. Click Substructure on the right panel, and then Transfer query. You now have a structure query and Subject Studied: mechanism query. Click: Search (Substances). You will get 38 reactions from around 80 documents. If instead you search reaction: structure of butadienesulfone + maleic anhydride => cyclohexene As drawn you don't get any hits. You can also try other structures if you wish, although if you search a very general structure (such as cyclohexene, substructure, as product - i.e., you have drawn the reaction arrow as above) you will find the search takes several minutes to complete. In such cases you can try Similar rather than Substructure as your search type. All this is possible because you can search text terms in Reaction Records in Reaxys. I hope this helps. Damon