This section describes various searches that can be performed in PubChem. Currently PubChem has three different search interfaces:
- PubChem homepage (http://pubchem.ncbi.nlm.nih.gov)
- PubChem Chemical Structure Search (https://pubchem.ncbi.nlm.nih.gov/search/search.cgi)
- PubChem Search (https://pubchem.ncbi.nlm.nih.gov/search/).
The PubChem homepage provides a search interface for all three primary databases (e.g., Substance, Compound, and BioAssay). However, the search box on the PubChem homepage can accepts textual keywords only, and it is difficult to input non-textual queries (such as chemical structures). The PubChem Chemical Structure Search allows users to perform various searches using both textual and non-textual queries. This search interface is integrated with PubChem Sketcher, which enables users to provide the 2-D structure of a molecule as a query for chemical structure search. While the PubChem Chemical Structure Search is limited to chemical structure searches, the PubChem Search allows users to search for bioassays, bioactivities, patents, and targets as well as chemical structures, but it is still in beta testing. In this module, we use the PubChem homepage for name/text search and the Chemical Structure Search for others.